Osteoarthritis Pain Pathway Identified

osteoarthritis pain pathway

A molecular signalling pathway has been identified as contributing towards osteoarthritis pain. The findings were discovered through a study carried out by researchers from the North Carolina State University.

The identification of the pain pathway could now help scientists to develop new treatments for those suffering with osteoarthritis. So, what did the study find and what does it mean for patients currently suffering with the condition? Find out everything you need to know below.

Understanding the latest study

The study used a mouse model with painful arthritis to show that blocking the pathway helped to eliminate pain. It also helped to restore mobility in the limb. It is the first study to identify an association between osteoarthritis pain and the pathway.

The GFRa3 system was already known to play a role in acute pain, but it hadn’t yet been associated with osteoarthritis. During the study, researchers found that GFRa3 was increased in sensory nerves in mice with chemically-induced osteoarthritis. After treating them with monoclonal antibodies, the limb function in the mice returned to normal within a couple of hours. This highlighted that the pathway does play a role in osteoarthritis pain.

It was essentially a proof-of-concept study that has revealed promising results. Now, researchers need to carry out more in-depth research of what triggers the pathway to signal pain in the first place.

Could it help develop new treatments moving forward?

The new study could lead to the development of new treatments. As shown in the mice model, monoclonal antibodies have shown to help eliminate pain and restore limb use in cases of osteoarthritis. However, now they need to be tested in human models to determine if they offer the same level of effectiveness.

So, future treatments could be developed based upon these initial findings. It won’t be anytime soon however, as further research still needs to be carried out. In the meantime, there are some effective ways to eliminate the pain associated with the condition.

MBST for osteoarthritis pain

MBST is one of the newest treatments available to address chronic pain. It is used to restore cartilage and heal the joints. For those with osteoarthritis in the knee or other joints, MBST can help to slow down to progression of the disease and eliminate pain and stiffness. Some studies have even shown the treatment can increase bone mass density.

MBST works by using the body’s electromagnetic energy. This is done through stimulating nuclei within hydrogen atoms. This activates specific cells, leading to the production of bone and cartilage. No other treatment can produce the same effects.

As it stands, MBST isn’t known to cause any side effects. It is one of the most effective treatments to help eliminate pain for those suffering with osteoarthritis in the joints. Book a consultation with MBST today; the first step is to be assessed for suitability prior to undergoing treatment.